Polypharmacy |
Core Concepts |
Advances in Aging Research Lecture Series: James Kloster, RPh., CGP Perspectives in Medication Safety in the Elderly July 17, 2008
Shrank WH, Polinski JM, Avorn J. Quality indicators for medication use in vulnerable elders. J Am Geriatr Soc. 2007;55 Suppl 2:S373-82.
Key Review Articles | top |
Ballantine, NH. Polypharmacy in the elderly: Maximizing benefit, minimizing harm. Crit Care Nurs Q. 2008;31( 1):40-45.
Chutka DS, Takahashi PY, Hoel RW. Inappropriate medications for elderly patients. Mayo Clin Proc. 2004;79(1):122-139.
Ferrario CG. Geropharmacology: A primer for advanced practice acute care and critical care nurses, part I. AACN Adv Crit Care. 2008;19( 1):23-35; quiz 36-7.
Fick DM, Cooper JW, Wade WE, Waller JL, MacleanJR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: Results of a US consensus panel of experts. Arch Intern Med.2003;163( 22):2716-2724.
Frazier SC. Health outcomes and polypharmacy in elderly individuals: An integrated literature review. J Gerontol Nurs. 2005;31( 9):4-11.
Fulton MM, Allen ER. Polypharmacy in the elderly: A literature review. J Am Acad Nurse Pract. 2005;17( 4):123-132.
Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5( 4):345-351.
Hayes BD, Klein-Schwartz W, Barrueto F,Jr. Polypharmacy and the geriatric patient. Clin Geriatr Med. 2007;23( 2):371-90, vii.
Milton JC, Hill-Smith I, Jackson SH. Prescribing for older people. BMJ. 2008;336( 7644):606-609.
Epidemiology | top |
Alkema GE, Wilber KH, Simmons WJ, Enguidanos SM, Frey D. Prevalence of potential medication problems among dually eligible older adults in Medicaid waiver services. Ann Pharmacother. 2007;41( 12):1971-1978.
Egger SS, Bachmann A, Hubmann N, Schlienger RG, Krahenbuhl S. Prevalence of potentially inappropriate medication use in elderly patients: Comparison between general medical and geriatric wards. Drugs Aging. 2006;23( 10):823-837.
Fick DM, Mion LC, Beers MH, L Waller J. Health outcomes associated with potentially inappropriate medication use in older adults. Res Nurs Health. 2008;31( 1):42-51.
Hanlon JT, Pieper CF, Hajjar ER, et al. Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. J Gerontol A Biol Sci Med Sci. 2006;61( 5):511-515.
Rancourt C, Moisan J, Baillargeon L, Verreault R, Laurin D, Gregoire JP. Potentially inappropriate prescriptions for older patients in long-term care. BMC Geriatr. 2004;4:9.
Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: How well can it be measured and optimised? Lancet.2007;370( 9582):173-184
Rossi MI, Young A, Maher R, et al. Polypharmacy and health beliefs in older outpatients. Am J Geriatr Pharmacother. 2007;5( 4):317-323.
Simon SR, Chan KA, Soumerai SB, et al. Potentially inappropriate medication use by elderly persons in U.S. health maintenance organizations, 2000-2001. J Am Geriatr Soc. 2005;53( 2):227-232.
Pathophysiology |
Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother. 2004;2( 4):274-302
McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56( 2):163-184.
Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther. 2007;82( 1):87-96
Assessment and Mangement | top |
Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: A meta-analysis. Am J Med. 2007;120( 8):713-719.
Lewis NJ, Bugdalski-Stutrud C, Abate MA, Blommel M, Wu CH, Gaither CA. The Medication Assessment Program: comprehensive medication assessments for persons taking multiple medications for chronic diseases. J Am Pharm Assoc (2003). 2008 Mar-Apr;48 (2):171-80.
Mallet L, Spinewine A, Huang A.The challenge of managing drug interactions in elderly people. Lancet.2007;370( 9582):185-19.
Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54( 10):1516-1523
Practice Guidelines |
Bergman-Evans B. Evidence-based guideline: Improving medication management for older adult clients. J Gerontol Nurs. 2006;32( 7):6-14.
National Guideline Clearinghouse (NGC). Guideline summary: Improving medication management for older adult clients. In: National Guideline Clearinghouse (NGC) [website]. Rockville (MD): Available: http://www.guideline.gov
Health Services and Models of Care | top |
Holmes HM, Sachs GA, Shega JW, Hougham GW, Cox Hayley D, Dale W. Integrating palliative medicine into the care of persons with advanced dementia: Identifying appropriate medication use. J Am Geriatr Soc. 2008.
Lewis NJ, Bugdalski-Stutrud C, Abate MA, Blommel M, Wu CH, Gaither CA. The medication assessment program: Comprehensive medication assessments for persons taking multiple medications for chronic diseases. J Am Pharm Assoc (2003). 2008;48( 2):171-180.
Rocchiccioli JT, Sanford J, Caplinger B. Polymedicine and aging. enhancing older adult care through advanced practitioners. GNPs and elder care pharmacists can help provide optimal pharmaceutical care. J Gerontol Nurs. 2007;33( 7):19-24.
Related Issues:(Social Factors, Undermedication, Health Disparities) |
Green JL, Hawley JN, Rask KJ. Is the number of prescribing physicians an independent risk factor for adverse drug events in an elderly outpatient population? Am J Geriatr Pharmacother. 2007;5( 1):31-39.
Jervis LL, Shore J, Hutt E, Manson SM. Suboptimal pharmacotherapy in a tribal nursing home. J Am Med Dir Assoc. 2007;8( 1):1-7.
Rossi MI, Young A, Maher R, et al. Polypharmacy and health beliefs in older outpatients. Am J Geriatr Pharmacother. 2007;5( 4):317-323.
Steinman MA, Maaravi Y, Walter LC, Hammerman-Rozenberg R, Stessman J. Evolution of medication use in Jerusalem elders: Results from the Jerusalem longitudinal study. Drugs Aging. 2007;24( 2):133-145.
PubMed Alerts | top |
Continuously updated articles addressing the issue of polypharmacy in the older population |
Interdisciplinary Issues |
Binch J, Beamon R, Clontz S, et al. Incorporating medication regimen reviews into the interdisciplinary care planning process. Geriatr Nurs. 2005;26( 2):89-93.
Pickering G. Frail elderly, nutritional status and drugs. Arch Gerontol Geriatr. 2004;38( 2):174-180.
Sokol KC, Knudsen JF, Li MM. Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management. J Clin Pharm Ther. 2007;32( 2):169-175.
